RAF Typhoon FGR4s have operated alongside France's air force in a joint strike targeting an subterranean weapons facility in Syrian territory operated by the Daesh militant organization, according to the British defence ministry.
The location, located using surveillance, was thought to be containing munitions and bombs, the release indicated, and was situated in hills just above the ancient city of Palmyra in central Syria.
"Our fighter planes used Paveway IV guided bombs to hit a several entry passages down to the site... early reports indicate the objective was successfully hit," the ministry announced.
There was no evidence of any civilian casualties in the attack on Saturday evening and all the aircraft returned to base without incident, the ministry further stated.
The Typhoon fighters were backed up by a Voyager aerial refuelling aircraft.
IS - also known as ISIS - imposed jihadist rule over significant areas in Syria and Iraq until 2019.
"This strike shows our UK leadership, and commitment to work closely with our partners, to eradicate any revival of the terrorist group and their harmful and extremist ideologies in the area," UK Defence Secretary the minister stated.
RAF aircraft have performed surveillance missions over Syrian airspace to "prevent any attempted comeback" of the group subsequent to its routing at the Baghuz confrontation in 2019, the MoD reported.
"I want to thank all the members of our armed forces participating in this strike for their professionalism and their bravery," he commented. "Including them were thousands of British troops deployed over the holidays. This mission, to take out militants who endanger our way of life, highlights how British military are ready to step up, throughout the year, keeping Britain secure at home and powerful internationally."
Last December, the American forces carried out what it called a "large-scale strike" targeting IS targets in Syria, following an assault claimed the lives of two US troops and a civilian linguist in the Palmyra area.
The United Nations says Islamic State still maintains roughly 5-7 thousand fighters in both countries.